Hepatitis B Virus X Protein Modulates Apoptosis in NRK-52E Cells and Activates Fas/FasL Through the MLK3-MKK7-JNK3 Signaling Pathway

Hepatitis B Virus X Protein Modulates Apoptosis in NRK-52E Cells and Activates Fas/FasL Through the MLK3-MKK7-JNK3 Signaling Pathway

Background/Aims: The hepatitis B virus X protein (HBx) contributes to HBV-induced injury of renal tubular cells and induces apoptosis via Fas/FasL up-regulation. However, the mechanism of Fas/FasL activation is unknown. Recent studies indicated that HBx induction of apoptosis in hepatic cells depend...

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Bibliographic Details
Main Authors: Ping He, Beiru Zhang, Dajun Liu, Xiaohui Bian, Detian Li, Yanqiu Wang, Guangping Sun, Guangyu Zhou
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
HBx
MLK3
MKK7
JNK3
NRK-52E cell
Apoptosis
Online Access:http://www.karger.com/Article/FullText/447846

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http://www.karger.com/Article/FullText/447846

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