Copper-Catalyzed Intramolecular Olefinic C(sp<sup>2</sup>)–H Amidation for the Synthesis of <i>γ</i>-Alkylidene-<i>γ</i>-lactams

Copper-Catalyzed Intramolecular Olefinic C(sp<sup>2</sup>)–H Amidation for the Synthesis of <i>γ</i>-Alkylidene-<i>γ</i>-lactams

Herein, we report the copper-catalyzed dehydrogenative C(sp<sup>2</sup>)–N bond formation of 4-pentenamides via nitrogen-centered radicals. This reaction provides a straightforward and efficient preparation method for <i>γ</i>-alkylidene-<i>γ</i>-lactams. Notably,...

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Bibliographic Details
Main Authors: Kanako Nozawa-Kumada, Masahito Hayashi, Eunsang Kwon, Masanori Shigeno, Akira Yada, Yoshinori Kondo
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Molecules
Subjects:
C(sp<sup>2</sup>)–H amidation
<i>γ</i>-alkylidene-<i>γ</i>-lactam
nitrogen-centered radical
cross-dehydrogenative coupling
copper-catalyst
Online Access:https://www.mdpi.com/1420-3049/28/18/6682

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https://www.mdpi.com/1420-3049/28/18/6682

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