Polymyxin Resistance in Clinical Isolates of K. pneumoniae in Brazil: Update on Molecular Mechanisms, Clonal Dissemination and Relationship With KPC-Producing Strains

Polymyxin Resistance in Clinical Isolates of K. pneumoniae in Brazil: Update on Molecular Mechanisms, Clonal Dissemination and Relationship With KPC-Producing Strains

In Brazil, the production of KPC-type carbapenemases in Enterobacteriales is endemic, leading to widespread use of polymyxins. In the present study, 502 Klebsiella pneumoniae isolates were evaluated for resistance to polymyxins, their genetic determinants and clonality, in addition to the presence o...

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Main Authors: Orlando C. Conceição-Neto, Bianca Santos da Costa, Leilane da Silva Pontes, Melise Chaves Silveira, Lívia Helena Justo-da-Silva, Ivson Cassiano de Oliveira Santos, Camila Bastos Tavares Teixeira, Thamirys Rachel Tavares e Oliveira, Fernanda Stephens Hermes, Teca Calcagno Galvão, L. Caetano M. Antunes, Cláudio Marcos Rocha-de-Souza, Ana P. D. Carvalho-Assef
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
polymyxin resistance
Klebsiella pneumoniae
antibiotic resistance
mcr gene
PhoPQ and PmrAB
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.898125/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2022.898125/full

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