All-trans retinoic acid increases the pathogenicity of the H9N2 influenza virus in mice

Abstract Background The H9N2 virus can infect not only birds but also humans. The pathogenicity of H9N2 virus infection is determined by an excessive immune response in the lung. All-trans retinoic acid (ATRA), the active metabolite of vitamin A, plays an important regulatory role and has been widel...

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Bibliographic Details
Main Authors: Xiaofei Niu, Hongyan Wang, Lihong Zhao, Pengjing Lian, Yu Bai, Jingyun Li, Jian Qiao
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Virology Journal
Subjects:
Online Access:https://doi.org/10.1186/s12985-022-01809-y