Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models

Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models

Abstract Background Lysosomal dysfunction has been implicated in a number of neurodegenerative diseases such as Parkinson’s disease (PD). Various molecular, clinical and genetic studies have highlighted a central role of lysosomal pathways and proteins in the pathogenesis of PD. Within PD pathology...

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Main Authors: Alice Drobny, Fanni Annamária Boros, Denise Balta, Susy Prieto Huarcaya, Deniz Caylioglu, Niyeti Qazi, Julia Vandrey, Yanni Schneider, Jan Philipp Dobert, Caleb Pitcairn, Joseph Robert Mazzulli, Friederike Zunke
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Translational Neurodegeneration
Subjects:
Dopaminergic neurons
iPSC-derived models
Lysosome
Parkinson’s disease
Protein trafficking
Synucleinopathy
Online Access:https://doi.org/10.1186/s40035-023-00363-z

Internet

https://doi.org/10.1186/s40035-023-00363-z

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