Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D

Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D

The giant protein titin performs structure-preserving functions in the sarcomere and is important for the passive stiffness (Fpassive) of cardiomyocytes. Protein kinase D (PKD) enzymes play crucial roles in regulating myocardial contraction, hypertrophy, and remodeling. PKD phosphorylates myofilamen...

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Bibliographic Details
Main Authors: Melissa Herwig, Detmar Kolijn, Mária Lódi, Soraya Hölper, Árpád Kovács, Zoltán Papp, Kornelia Jaquet, Peter Haldenwang, Cris Dos Remedios, Peter H. Reusch, Andreas Mügge, Marcus Krüger, Jens Fielitz, Wolfgang A. Linke, Nazha Hamdani
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Physiology
Subjects:
titin
HCM
PKD
Hsp27
stiffness
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00240/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00240/full

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