Systems analysis of immune responses to attenuated P. falciparum malaria sporozoite vaccination reveals excessive inflammatory signatures correlating with impaired immunity.

Systems analysis of immune responses to attenuated P. falciparum malaria sporozoite vaccination reveals excessive inflammatory signatures correlating with impaired immunity.

Immunization with radiation-attenuated sporozoites (RAS) can confer sterilizing protection against malaria, although the mechanisms behind this protection are incompletely understood. We performed a systems biology analysis of samples from the Immunization by Mosquito with Radiation Attenuated Sporo...

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Bibliographic Details
Main Authors: Ying Du, Nina Hertoghs, Fergal J Duffy, Jason Carnes, Suzanne M McDermott, Maxwell L Neal, Katharine V Schwedhelm, M Juliana McElrath, Stephen C De Rosa, John D Aitchison, Kenneth D Stuart
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010282

Internet

https://doi.org/10.1371/journal.ppat.1010282

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