An Expeditious, Green and Protecting-Group-Free Synthesis of a Potent Secondary Metabolite Calebin-A and Its Analogues
Abstract The synthesis of Calebin-A (10a) and analogues (10b–d), which are minor but pharmacologically active components (<0.01% of the oleoresin) of curcuma longa, is described. This flexible synthesis is achieved under near neutral conditions in water/solvent biphasic medium at room temperature...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2017-03-01
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| Series: | SynOpen |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1591507 |
| _version_ | 1818152441032474624 |
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| author | Anju Majeed Kalyanam Nagabhushanam Muhammed Majeed Samuel Manoharan Thomas Nooruddin Thajuddin |
| author_facet | Anju Majeed Kalyanam Nagabhushanam Muhammed Majeed Samuel Manoharan Thomas Nooruddin Thajuddin |
| author_sort | Anju Majeed |
| collection | DOAJ |
| description | Abstract
The synthesis of Calebin-A (10a) and analogues (10b–d), which are minor but pharmacologically active components (<0.01% of the oleoresin) of curcuma longa, is described. This flexible synthesis is achieved under near neutral conditions in water/solvent biphasic medium at room temperature without involving any protecting groups. |
| first_indexed | 2024-12-11T13:54:46Z |
| format | Article |
| id | doaj.art-6c7027c1d63842b8b2b2f88a8dc78c21 |
| institution | Directory Open Access Journal |
| issn | 2509-9396 |
| language | English |
| last_indexed | 2024-12-11T13:54:46Z |
| publishDate | 2017-03-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | SynOpen |
| spelling | doaj.art-6c7027c1d63842b8b2b2f88a8dc78c212022-12-22T01:04:06ZengGeorg Thieme Verlag KGSynOpen2509-93962017-03-0101010125012810.1055/s-0036-1591507An Expeditious, Green and Protecting-Group-Free Synthesis of a Potent Secondary Metabolite Calebin-A and Its AnaloguesAnju Majeed0Kalyanam Nagabhushanam1Muhammed Majeed2Samuel Manoharan Thomas3Nooruddin Thajuddin4Sami Labs Ltd., 19/1 & 19/2, I Main, II PhaseSabinsa CorporationSami Labs Ltd., 19/1 & 19/2, I Main, II PhaseSami Labs Ltd., 19/1 & 19/2, I Main, II PhaseDepartment of Microbiology, Faculty of Science, Engineering & TechnologyAbstract The synthesis of Calebin-A (10a) and analogues (10b–d), which are minor but pharmacologically active components (<0.01% of the oleoresin) of curcuma longa, is described. This flexible synthesis is achieved under near neutral conditions in water/solvent biphasic medium at room temperature without involving any protecting groups.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1591507calebin-a curcuma longa ferulic acid esterphase-transfer catalyst (ptc)green synthesis |
| spellingShingle | Anju Majeed Kalyanam Nagabhushanam Muhammed Majeed Samuel Manoharan Thomas Nooruddin Thajuddin An Expeditious, Green and Protecting-Group-Free Synthesis of a Potent Secondary Metabolite Calebin-A and Its Analogues SynOpen calebin-a curcuma longa ferulic acid ester phase-transfer catalyst (ptc) green synthesis |
| title | An Expeditious, Green and Protecting-Group-Free Synthesis of a Potent Secondary Metabolite Calebin-A and Its Analogues |
| title_full | An Expeditious, Green and Protecting-Group-Free Synthesis of a Potent Secondary Metabolite Calebin-A and Its Analogues |
| title_fullStr | An Expeditious, Green and Protecting-Group-Free Synthesis of a Potent Secondary Metabolite Calebin-A and Its Analogues |
| title_full_unstemmed | An Expeditious, Green and Protecting-Group-Free Synthesis of a Potent Secondary Metabolite Calebin-A and Its Analogues |
| title_short | An Expeditious, Green and Protecting-Group-Free Synthesis of a Potent Secondary Metabolite Calebin-A and Its Analogues |
| title_sort | expeditious green and protecting group free synthesis of a potent secondary metabolite calebin a and its analogues |
| topic | calebin-a curcuma longa ferulic acid ester phase-transfer catalyst (ptc) green synthesis |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1591507 |
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