Therapeutic Potentials of Poly (ADP‐Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting

Therapeutic Potentials of Poly (ADP‐Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting

Abstract Poly (ADP‐ribose) polymerase 1 (PARP1) plays a fundamental role in DNA repair and gene expression. Excessive PARP1 hyperactivation, however, has been associated with cell death. PARP1 and/or its activity are dysregulated in the immune and central nervous system of multiple sclerosis (MS) pa...

Full description

Bibliographic Details
Main Authors: Yan Wang, David Pleasure, Wenbin Deng, Fuzheng Guo
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Advanced Science
Subjects:
demyelination
inflammatory demyelinating disease
multiple sclerosis
neuroinflammation
neuronal/axonal degeneration
PARP1
Online Access:https://doi.org/10.1002/advs.202102853

Internet

https://doi.org/10.1002/advs.202102853

Similar Items