Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier – phenotypic variability in autosomal dominant Alzheimer’s disease

Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier – phenotypic variability in autosomal dominant Alzheimer’s disease

Abstract The discovery of mutations associated with familial forms of Alzheimer’s disease (AD), has brought imperative insights into basic mechanisms of disease pathogenesis and progression and has allowed researchers to create animal models that assist in the elucidation of the molecular pathways a...

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Bibliographic Details
Main Authors: Grace M. Lloyd, Jorge A. Trejo-Lopez, Yuxing Xia, Karen N. McFarland, Sarah J. Lincoln, Nilüfer Ertekin-Taner, Benoit I. Giasson, Anthony T. Yachnis, Stefan Prokop
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Amyloid precursor protein
Beta-amyloid
Cerebral amyloid angiopathy
London mutation
APOE
Online Access:http://link.springer.com/article/10.1186/s40478-020-0891-3

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http://link.springer.com/article/10.1186/s40478-020-0891-3

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