Computational Analysis of Mutations in the Receptor-Binding Domain of SARS-CoV-2 Spike and Their Effects on Antibody Binding

Computational Analysis of Mutations in the Receptor-Binding Domain of SARS-CoV-2 Spike and Their Effects on Antibody Binding

Currently, SARS-CoV-2 causing coronavirus disease 2019 (COVID-19) is responsible for one of the most deleterious pandemics of our time. The interaction between the ACE2 receptors at the surface of human cells and the viral Spike (S) protein triggers the infection, making the receptor-binding domain...

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Bibliographic Details
Main Authors: Marine E. Bozdaganyan, Konstantin V. Shaitan, Mikhail P. Kirpichnikov, Olga S. Sokolova, Philipp S. Orekhov
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Viruses
Subjects:
coronaviruses
virus–host interactions
binding free energy
antigenic escape
computational mutagenesis
hACE2
Online Access:https://www.mdpi.com/1999-4915/14/2/295

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https://www.mdpi.com/1999-4915/14/2/295

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