Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor

Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor

Huntington's disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion in the Huntingtin gene (HTT), translated into a Huntingtin protein with a polyglutamine expansion. There is preferential loss of medium spiny neurons within the striatum and cortical pyramidal neurons. Pri...

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Bibliographic Details
Main Authors: Chelsy R. Eddings, Nicolas Arbez, Sergey Akimov, Michal Geva, Michael R. Hayden, Christopher A. Ross
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Neurobiology of Disease
Subjects:
Neuroprotection
Huntingtin toxicity
Huntington's disease
Mutant-huntingtin
Pridopidine
3PPP
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118306120

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http://www.sciencedirect.com/science/article/pii/S0969996118306120

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