Investigation of Molecular Weight, Polymer Concentration and Process Parameters Factors on the Sustained Release of the Anti-Multiple-Sclerosis Agent Teriflunomide from Poly(<i>ε</i>-caprolactone) Electrospun Nanofibrous Matrices

Investigation of Molecular Weight, Polymer Concentration and Process Parameters Factors on the Sustained Release of the Anti-Multiple-Sclerosis Agent Teriflunomide from Poly(<i>ε</i>-caprolactone) Electrospun Nanofibrous Matrices

In the current work, a series of PCL polyesters with different molecular weights was synthesized and used for the fabrication of nanofibrous patches via electrospinning, as sustained release matrices for leflunomide’s active metabolite, teriflunomide (TFL). The electrospinning conditions for each sa...

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Bibliographic Details
Main Authors: Nikolaos D. Bikiaris, Ioanna Koumentakou, Georgia Michailidou, Margaritis Kostoglou, Marilena Vlachou, Panagiotis Barmpalexis, Evangelos Karavas, George Z. Papageorgiou
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceutics
Subjects:
electrospinning
poly(ε-caprolactone) PCL
nanofibers
process parameters
teriflunomide
drug release
Online Access:https://www.mdpi.com/1999-4923/14/8/1693

Internet

https://www.mdpi.com/1999-4923/14/8/1693

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