Ser-634 and Ser-636 of Kaposi’s sarcoma-associated herpesvirus RTA are involved in transactivation and are potential CDK9 phosphorylation sites

Ser-634 and Ser-636 of Kaposi’s sarcoma-associated herpesvirus RTA are involved in transactivation and are potential CDK9 phosphorylation sites

The replication and transcription activator (RTA) of Kaposi’s sarcoma-associated herpesvirus (KSHV), K-RTA, is a lytic switch protein that moderates the reactivation process of KSHV latency. By mass spectrometric analysis of affinity-purified K-RTA, we showed that Thr-513 or Thr-514 was the primary...

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Bibliographic Details
Main Authors: Wan-Hua eTsai, Pei-Wen eWang, Shu-Yu eLin, I-Lin eWu, Ying-Chieh eKo, Yu-Lian eChen, Mengtao eLi, Su-Fang eLin
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-02-01
Series:Frontiers in Microbiology
Subjects:
Phosphorylation
Kaposi’s sarcoma-associated herpesvirus (KSHV)
negative elongation factor B (NELF-B)
replication and transcription activator (RTA)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00060/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00060/full

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