β-Amyloid Fragment 25–35 Causes Mitochondrial Dysfunction in Primary Cortical Neurons

β-Amyloid Fragment 25–35 Causes Mitochondrial Dysfunction in Primary Cortical Neurons

β-Amyloid deposition and compromised energy metabolism both occur in vulnerable brain regions in Alzheimer's disease. It is not known whether β-amyloid is the cause of impairment of energy metabolism, nor whether impaired energy metabolism is specific to neurons. Our results, using primary neur...

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Bibliographic Details
Main Authors: C.S. Casley, J.M. Land, M.A. Sharpe, J.B. Clark, M.R. Duchen, L. Canevari
Format: Article
Language:English
Published: Elsevier 2002-08-01
Series:Neurobiology of Disease
Subjects:
β-Amyloid
Alzheimer's disease
mitochondria
neuron
astrocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102905164

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http://www.sciencedirect.com/science/article/pii/S0969996102905164

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