Genetic susceptibility loci for Chlamydia trachomatis endometrial infection influence expression of genes involved in T cell function, tryptophan metabolism and epithelial integrity

Genetic susceptibility loci for Chlamydia trachomatis endometrial infection influence expression of genes involved in T cell function, tryptophan metabolism and epithelial integrity

ObjectivesIdentify genetic loci of enhanced susceptibility to Chlamydial trachomatis (Ct) upper genital tract infection in women.MethodsWe performed an integrated analysis of DNA genotypes and blood-derived mRNA profiles from 200 Ct-exposed women to identify expression quantitative trait loci (eQTL)...

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Bibliographic Details
Main Authors: Wujuan Zhong, Avinash Kollipara, Yutong Liu, Yuhan Wang, Catherine M. O’Connell, Taylor B. Poston, Kacy Yount, Harold C. Wiesenfeld, Sharon L. Hillier, Yun Li, Toni Darville, Xiaojing Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
Chlamydial trachomatis
upper genital tract infection in women
genetic marker for host susceptibility
cis-eQTLs
blood T cells and T cell subsets
CD151
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1001255/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1001255/full

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