Upregulation of PGC-1α expression by pioglitazone mediates prevention of sepsis-induced acute lung injury

Upregulation of PGC-1α expression by pioglitazone mediates prevention of sepsis-induced acute lung injury

Abstract The imbalance between pro-inflammatory M1 and anti-inflammatory M2 macrophages plays a critical role in the pathogenesis of sepsis-induced acute lung injury (ALI). Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) may modulate macrophage polarization toward the M...

Full description

Bibliographic Details
Main Authors: Jing Tang, Wenzhu Dong, Dan Wang, Qin Deng, Honggang Guo, Guibao Xiao
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2024-03-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Pioglitazone
Sepsis-induced acute lung injury
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Macrophage polarization
Inflammation
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2024000100622&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2024000100622&lng=en&tlng=en

Similar Items