Upregulation of PGC-1α expression by pioglitazone mediates prevention of sepsis-induced acute lung injury

Upregulation of PGC-1α expression by pioglitazone mediates prevention of sepsis-induced acute lung injury

Abstract The imbalance between pro-inflammatory M1 and anti-inflammatory M2 macrophages plays a critical role in the pathogenesis of sepsis-induced acute lung injury (ALI). Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) may modulate macrophage polarization toward the M...

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Bibliographic Details
Main Authors:	Jing Tang, Wenzhu Dong, Dan Wang, Qin Deng, Honggang Guo, Guibao Xiao
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2024-03-01
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	Pioglitazone Sepsis-induced acute lung injury Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Macrophage polarization Inflammation
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2024000100622&lng=en&tlng=en

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