Multi-Omics Characterization of Inflammatory Bowel Disease-Induced Hyperplasia/Dysplasia in the <i>Rag2<sup>−/−</sup></i>/<i>Il10<sup>−/−</sup></i> Mouse Model

Multi-Omics Characterization of Inflammatory Bowel Disease-Induced Hyperplasia/Dysplasia in the <i>Rag2<sup>−/−</sup></i>/<i>Il10<sup>−/−</sup></i> Mouse Model

Epigenetic dysregulation is hypothesized to play a role in the observed association between inflammatory bowel disease (IBD) and colon tumor development. In the present work, DNA methylome, hydroxymethylome, and transcriptome analyses were conducted in proximal colon tissues harvested from the <i...

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Bibliographic Details
Main Authors: Qiyuan Han, Thomas J. Y. Kono, Charles G. Knutson, Nicola M. Parry, Christopher L. Seiler, James G. Fox, Steven R. Tannenbaum, Natalia Y. Tretyakova
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
inflammatory bowel disease
hyperplasia
dysplasia
colorectal cancer
transcriptome
methylome
Online Access:https://www.mdpi.com/1422-0067/22/1/364

Internet

https://www.mdpi.com/1422-0067/22/1/364

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