Oxidatively stressed extracellular microenvironment drives fibroblast activation and kidney fibrosis

Oxidatively stressed extracellular microenvironment drives fibroblast activation and kidney fibrosis

Kidney fibrosis is associated with tubular injury, oxidative stress and activation of interstitial fibroblasts. However, whether these events are somehow connected is poorly understood. In this study, we show that glutathione peroxidase-3 (GPX3) depletion in renal tubular epithelium after kidney inj...

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Bibliographic Details
Main Authors: Li Li, Meizhi Lu, Yiling Peng, Junxin Huang, Xiaoman Tang, Jian Chen, Jing Li, Xue Hong, Meizhi He, Haiyan Fu, Ruiyuan Liu, Fan Fan Hou, Lili Zhou, Youhua Liu
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Redox Biology
Subjects:
Oxidative stress
Extracellular microenvironment
GPX3
Fibroblast activation
Kidney fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723002690

Internet

http://www.sciencedirect.com/science/article/pii/S2213231723002690

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