SMAC Mimetics Synergistically Cooperate with HDAC Inhibitors Enhancing TNF-α Autocrine Signaling

SMAC Mimetics Synergistically Cooperate with HDAC Inhibitors Enhancing TNF-α Autocrine Signaling

The overexpression of inhibitor of apoptosis (IAP) proteins is strongly related to poor survival of women with ovarian cancer. Recurrent ovarian cancers resist apoptosis due to the dysregulation of IAP proteins. Mechanistically, Second Mitochondrial Activator of Caspases (SMAC) mimetics suppress the...

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Bibliographic Details
Main Authors: Yusuke Shibuya, Kei Kudo, Kristen P. Zeligs, David Anderson, Lidia Hernandez, Franklin Ning, Christopher B. Cole, Maria Fergusson, Noemi Kedei, John Lyons, Jason Taylor, Soumya Korrapati, Christina M. Annunziata
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
ovarian cancer
SMAC mimetics
IAP inhibitor
HDAC inhibitor
TNF-α
Online Access:https://www.mdpi.com/2072-6694/15/4/1315

Internet

https://www.mdpi.com/2072-6694/15/4/1315

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