Mechanisms of TSC-mediated control of synapse assembly and axon guidance.

Mechanisms of TSC-mediated control of synapse assembly and axon guidance.

Tuberous sclerosis complex is a dominant genetic disorder produced by mutations in either of two tumor suppressor genes, TSC1 and TSC2; it is characterized by hamartomatous tumors, and is associated with severe neurological and behavioral disturbances. Mutations in TSC1 or TSC2 deregulate a conserve...

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Bibliographic Details
Main Authors: Sarah Knox, Hong Ge, Brian D Dimitroff, Yi Ren, Katie A Howe, Andrew M Arsham, Mathew C Easterday, Thomas P Neufeld, Michael B O'Connor, Scott B Selleck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1847706?pdf=render

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http://europepmc.org/articles/PMC1847706?pdf=render

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