The protein phosphatase PP6 promotes RIPK1-dependent PANoptosis

Abstract Background The innate immune system serves as the first line of host defense. Transforming growth factor-β–activated kinase 1 (TAK1) is a key regulator of innate immunity, cell survival, and cellular homeostasis. Because of its importance in immunity, several pathogens have evolved to carry...

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Bibliographic Details
Main Authors: Ratnakar R. Bynigeri, R. K. Subbarao Malireddi, Raghvendra Mall, Jon P. Connelly, Shondra M. Pruett-Miller, Thirumala-Devi Kanneganti
Format: Article
Language:English
Published: BMC 2024-05-01
Series:BMC Biology
Subjects:
Online Access:https://doi.org/10.1186/s12915-024-01901-5