Repositioning Canagliflozin for Mitigation of Aluminium Chloride-Induced Alzheimer’s Disease: Involvement of TXNIP/NLRP3 Inflammasome Axis, Mitochondrial Dysfunction, and SIRT1/HMGB1 Signalling

Repositioning Canagliflozin for Mitigation of Aluminium Chloride-Induced Alzheimer’s Disease: Involvement of TXNIP/NLRP3 Inflammasome Axis, Mitochondrial Dysfunction, and SIRT1/HMGB1 Signalling

<i>Background and Objectives:</i> Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the world. Due to failure of the traditional drugs to produce a complete cure for AD, the search for new safe and effective lines of therapy has attracted the attention of ongoing...

Full description

Bibliographic Details
Main Authors: Hemat A. Elariny, Ahmed M. Kabel, Heba Mohammed Refat M. Selim, Azza I. Helal, Doaa Abdelrahman, Hany M. Borg, Mennatallah A. Elkady, Lamees M. Dawood, Mohamed F. El-Badawy, Haifa Faisal A. Almalawi, El-Shaimaa A. Arafa, Shuruq E. Alsufyani, Hany H. Arab
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Medicina
Subjects:
canagliflozin
aluminium chloride
Alzheimer’s disease
sirtuin-1
behavioural changes
rats
Online Access:https://www.mdpi.com/1648-9144/60/11/1805

Internet

https://www.mdpi.com/1648-9144/60/11/1805

Similar Items