Molecular basis for inhibition of adhesin-mediated bacterial-host interactions through a peptide-binding domain

Molecular basis for inhibition of adhesin-mediated bacterial-host interactions through a peptide-binding domain

Summary: Infections typically begin with pathogens adhering to host cells. For bacteria, this adhesion can occur through specific ligand-binding domains. We identify a 20-kDa peptide-binding domain (PBD) in a 1.5-MDa RTX adhesin of a Gram-negative marine bacterium that colonizes diatoms. The crystal...

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Bibliographic Details
Main Authors: Shuaiqi Guo, Hossein Zahiri, Corey Stevens, Daniel C. Spaanderman, Lech-Gustav Milroy, Christian Ottmann, Luc Brunsveld, Ilja K. Voets, Peter L. Davies
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Cell Reports
Subjects:
structural biology
bacteria-host interaction
bacterial adhesins
X-ray crystallography
peptide inhibitors
peptide-binding domain
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721014807

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http://www.sciencedirect.com/science/article/pii/S2211124721014807

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