LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia

LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia

Abstract Background Cancer cachexia is a deadly wasting syndrome that accompanies various diseases (including ~ 50% of cancers). Clinical studies have established that cachexia is not a nutritional deficiency and is linked to expression of certain proteins (e.g., interleukin-6 and C-reactive protein...

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Bibliographic Details
Main Authors: Dong Wang, Xiaohui Li, Defeng Jiao, Ying Cai, Liting Qian, Yiqing Shen, Yichen Lu, Yonggang Zhou, Binqing Fu, Rui Sun, Zhigang Tian, Xiaohu Zheng, Haiming Wei
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Hematology & Oncology
Subjects:
Cachexia
Lung cancer
LCN2
Ferroptosis
Neutrophils
Online Access:https://doi.org/10.1186/s13045-023-01429-1

Internet

https://doi.org/10.1186/s13045-023-01429-1

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