Tumor Killing by CD4+ T Cells Is Mediated via Induction of Inducible Nitric Oxide Synthase-Dependent Macrophage Cytotoxicity

Tumor Killing by CD4+ T Cells Is Mediated via Induction of Inducible Nitric Oxide Synthase-Dependent Macrophage Cytotoxicity

CD4+ T cells can induce potent anti-tumor immune responses. Due to the lack of MHC class II expression in most cancer cells, antigen recognition occurs indirectly via uptake and presentation on tumor-infiltrating antigen-presenting cells (APCs). Activation of the APCs can induce tumor rejection, but...

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Bibliographic Details
Main Authors: Marte Fauskanger, Ole Audun Werner Haabeth, Frode Miltzow Skjeldal, Bjarne Bogen, Anders Aune Tveita
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
macrophage
CD4+ T cell
immunotherapy
myeloma
nitric oxide
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01684/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01684/full

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