Asymmetric α-benzylation of cyclic ketones enabled by concurrent chemical aldol condensation and biocatalytic reduction

Asymmetric α-benzylation of cyclic ketones enabled by concurrent chemical aldol condensation and biocatalytic reduction

Abstract Chemoenzymatic cascade catalysis has emerged as a revolutionary tool for streamlining traditional retrosynthetic disconnections, creating new possibilities for the asymmetric synthesis of valuable chiral compounds. Here we construct a one-pot concurrent chemoenzymatic cascade by integrating...

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Bibliographic Details
Main Authors: Yunting Liu, Teng Ma, Zhongxu Guo, Liya Zhou, Guanhua Liu, Ying He, Li Ma, Jing Gao, Jing Bai, Frank Hollmann, Yanjun Jiang
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44452-z

Internet

https://doi.org/10.1038/s41467-023-44452-z

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