Oxime Therapy for Brain AChE Reactivation and Neuroprotection after Organophosphate Poisoning

Oxime Therapy for Brain AChE Reactivation and Neuroprotection after Organophosphate Poisoning

One of the main problems in the treatment of poisoning with organophosphorus (OPs) inhibitors of acetylcholinesterase (AChE) is low ability of existing reactivators of AChE that are used as antidotes to cross the blood-brain barrier (BBB). In this work, modified cationic liposomes were developed tha...

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Bibliographic Details
Main Authors: Darya A. Kuznetsova, Gulnara A. Gaynanova, Elmira A. Vasilieva, Rais V. Pavlov, Irina V. Zueva, Vasily M. Babaev, Denis M. Kuznetsov, Alexandra D. Voloshina, Konstantin A. Petrov, Lucia Y. Zakharova, Oleg G. Sinyashin
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceutics
Subjects:
cationic liposome
imidazolium surfactant
targeted drug delivery
acetylcholinesterase reactivation
blood-brain barrier
Online Access:https://www.mdpi.com/1999-4923/14/9/1950

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https://www.mdpi.com/1999-4923/14/9/1950

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