Swelling and Salt Formation in Ibuprofen and Tranexamic Acid-Containing Tablets during High-Temperature Storage

Swelling and Salt Formation in Ibuprofen and Tranexamic Acid-Containing Tablets during High-Temperature Storage

Ibuprofen (IBP)- and Tranexamic acid (TXA)-containing tablets are known to swell when stored at high temperatures, but the mechanism of swelling is unknown. In this study, we investigated the possible mechanism of swelling with high-temperature storage. Differential scanning calorimetry (DSC) and po...

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Bibliographic Details
Main Authors: Yuto Kawano, Yoshiharu Tanaka, Nanami Hata, Yuki Yoshiike, Masato Nakajima, Etsuo Yonemochi, Nobuhiro Ishihara
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Crystals
Subjects:
ibuprofen
tranexamic acid
salt
crystal structure
swell
Online Access:https://www.mdpi.com/2073-4352/12/10/1420

Internet

https://www.mdpi.com/2073-4352/12/10/1420

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