Swelling and Salt Formation in Ibuprofen and Tranexamic Acid-Containing Tablets during High-Temperature Storage
Ibuprofen (IBP)- and Tranexamic acid (TXA)-containing tablets are known to swell when stored at high temperatures, but the mechanism of swelling is unknown. In this study, we investigated the possible mechanism of swelling with high-temperature storage. Differential scanning calorimetry (DSC) and po...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Crystals |
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| Online Access: | https://www.mdpi.com/2073-4352/12/10/1420 |
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| author | Yuto Kawano Yoshiharu Tanaka Nanami Hata Yuki Yoshiike Masato Nakajima Etsuo Yonemochi Nobuhiro Ishihara |
| author_facet | Yuto Kawano Yoshiharu Tanaka Nanami Hata Yuki Yoshiike Masato Nakajima Etsuo Yonemochi Nobuhiro Ishihara |
| author_sort | Yuto Kawano |
| collection | DOAJ |
| description | Ibuprofen (IBP)- and Tranexamic acid (TXA)-containing tablets are known to swell when stored at high temperatures, but the mechanism of swelling is unknown. In this study, we investigated the possible mechanism of swelling with high-temperature storage. Differential scanning calorimetry (DSC) and powder X-ray diffractometry (PXRD) analyses showed that a new complex was formed in swollen tablets, when stored at 50 °C for 60 days. Additionally, we prepared single crystals of IBP and TXA, and analyzed them using single crystal X-ray diffractometry (SCXRD), to identify the new complex formed during storage. This revealed that the single crystal was a salt consisting of IBP and TXA. The PXRD peak of the salt simulated by SCXRD matched that of the PXRD peak of the swollen tablet after storage. These results suggest a close relationship between the swelling and crystal structures of IBP and TXA. |
| first_indexed | 2024-03-09T20:25:19Z |
| format | Article |
| id | doaj.art-6c99e5e82dbc4d059046dfb129c72e11 |
| institution | Directory Open Access Journal |
| issn | 2073-4352 |
| language | English |
| last_indexed | 2024-03-09T20:25:19Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Crystals |
| spelling | doaj.art-6c99e5e82dbc4d059046dfb129c72e112023-11-23T23:38:09ZengMDPI AGCrystals2073-43522022-10-011210142010.3390/cryst12101420Swelling and Salt Formation in Ibuprofen and Tranexamic Acid-Containing Tablets during High-Temperature StorageYuto Kawano0Yoshiharu Tanaka1Nanami Hata2Yuki Yoshiike3Masato Nakajima4Etsuo Yonemochi5Nobuhiro Ishihara6R&D Center, Zenyaku Kogyo Co., Ltd., 4-7-1 Minamiosawa, Tokyo 192-0364, JapanR&D Center, Zenyaku Kogyo Co., Ltd., 4-7-1 Minamiosawa, Tokyo 192-0364, JapanR&D Center, Zenyaku Kogyo Co., Ltd., 4-7-1 Minamiosawa, Tokyo 192-0364, JapanR&D Center, Zenyaku Kogyo Co., Ltd., 4-7-1 Minamiosawa, Tokyo 192-0364, JapanR&D Center, Zenyaku Kogyo Co., Ltd., 4-7-1 Minamiosawa, Tokyo 192-0364, JapanDepartment of Physical Chemistry, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501, JapanR&D Center, Zenyaku Kogyo Co., Ltd., 4-7-1 Minamiosawa, Tokyo 192-0364, JapanIbuprofen (IBP)- and Tranexamic acid (TXA)-containing tablets are known to swell when stored at high temperatures, but the mechanism of swelling is unknown. In this study, we investigated the possible mechanism of swelling with high-temperature storage. Differential scanning calorimetry (DSC) and powder X-ray diffractometry (PXRD) analyses showed that a new complex was formed in swollen tablets, when stored at 50 °C for 60 days. Additionally, we prepared single crystals of IBP and TXA, and analyzed them using single crystal X-ray diffractometry (SCXRD), to identify the new complex formed during storage. This revealed that the single crystal was a salt consisting of IBP and TXA. The PXRD peak of the salt simulated by SCXRD matched that of the PXRD peak of the swollen tablet after storage. These results suggest a close relationship between the swelling and crystal structures of IBP and TXA.https://www.mdpi.com/2073-4352/12/10/1420ibuprofentranexamic acidsaltcrystal structureswell |
| spellingShingle | Yuto Kawano Yoshiharu Tanaka Nanami Hata Yuki Yoshiike Masato Nakajima Etsuo Yonemochi Nobuhiro Ishihara Swelling and Salt Formation in Ibuprofen and Tranexamic Acid-Containing Tablets during High-Temperature Storage Crystals ibuprofen tranexamic acid salt crystal structure swell |
| title | Swelling and Salt Formation in Ibuprofen and Tranexamic Acid-Containing Tablets during High-Temperature Storage |
| title_full | Swelling and Salt Formation in Ibuprofen and Tranexamic Acid-Containing Tablets during High-Temperature Storage |
| title_fullStr | Swelling and Salt Formation in Ibuprofen and Tranexamic Acid-Containing Tablets during High-Temperature Storage |
| title_full_unstemmed | Swelling and Salt Formation in Ibuprofen and Tranexamic Acid-Containing Tablets during High-Temperature Storage |
| title_short | Swelling and Salt Formation in Ibuprofen and Tranexamic Acid-Containing Tablets during High-Temperature Storage |
| title_sort | swelling and salt formation in ibuprofen and tranexamic acid containing tablets during high temperature storage |
| topic | ibuprofen tranexamic acid salt crystal structure swell |
| url | https://www.mdpi.com/2073-4352/12/10/1420 |
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