A novel anti-B7-H3 chimeric antigen receptor from a single-chain antibody library for immunotherapy of solid cancers

A novel anti-B7-H3 chimeric antigen receptor from a single-chain antibody library for immunotherapy of solid cancers

B7-H3 (CD276) has emerged as a target for cancer immunotherapy by virtue of consistent expression in many malignancies, relative absence from healthy tissues, and an emerging role as a driver of tumor immune inhibition. Recent studies have reported B7-H3 to be a suitable target for chimeric antigen...

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Bibliographic Details
Main Authors: Kathleen Birley, Clara Leboreiro-Babe, Enrique Miranda Rota, Magdalena Buschhaus, Artemis Gavriil, Alice Vitali, Maria Alonso-Ferrero, Lee Hopwood, Lara Parienti, Gabrielle Ferry, Barry Flutter, Nourredine Himoudi, Kerry Chester, John Anderson
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
CAR-T cell
B7-H3
phage display
pediatric cancer
solid tumor
neuroblastoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522001073

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http://www.sciencedirect.com/science/article/pii/S2372770522001073

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