Notochordal cell-derived matrix inhibits MAPK signaling in the degenerative disc environment

Notochordal cell-derived matrix inhibits MAPK signaling in the degenerative disc environment

Chronic low back pain is often caused by intervertebral disc (IVD) degeneration. Preceding this degenerative process, the main cellular phenotype in the nucleus pulposus shifts from notochordal cells (NCs) to nucleus pulposus cells (NPCs). In previous studies, porcine NC-derived matrix (NCM), contai...

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Bibliographic Details
Main Authors: LT Laagland, FC Bach, FM Riemers, G Erdmann, TS Braun, GGH van den Akker, TC Schmitz, LB Creemers, C Sachse, CL Le Maitre, TJM Welting, K Ito, MF Templin, MA Tryfonidou
Format: Article
Language:English
Published: Forum Multimedia Publishing LLC 2023-11-01
Series:European Cells & Materials
Subjects:
intervertebral disc degeneration
inflammation
notochordal cells
extracellular matrix
mitogen-activated protein kinase pathway
dual specificity phosphatase
Online Access:https://www.ecmjournal.org/papers/vol046/vol046a04.php

Internet

https://www.ecmjournal.org/papers/vol046/vol046a04.php

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