The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice

The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice

Abstract Background Intestinal tumorigenesis is promoted by myeloid differentiation primary response gene 88 (MyD88) activation in response to the components of microbiota in Apc Min/+ mice. Microbiota also contains double-stranded RNA (dsRNA), a ligand for TLR3, which activates the toll-like recept...

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Bibliographic Details
Main Authors: Junya Ono, Hiroaki Shime, Hiromi Takaki, Ken Takashima, Kenji Funami, Sumito Yoshida, Yohei Takeda, Misako Matsumoto, Masanori Kasahara, Tsukasa Seya
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Journal of Biomedical Science
Subjects:
TLR3
TICAM-1 (TRIF)
c-Myc
Intestinal polyposis
Online Access:http://link.springer.com/article/10.1186/s12929-017-0387-z

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http://link.springer.com/article/10.1186/s12929-017-0387-z

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