Cardiac-Specific Expression of Cre Recombinase Leads to Age-Related Cardiac Dysfunction Associated with Tumor-like Growth of Atrial Cardiomyocyte and Ventricular Fibrosis and Ferroptosis

Cardiac-Specific Expression of Cre Recombinase Leads to Age-Related Cardiac Dysfunction Associated with Tumor-like Growth of Atrial Cardiomyocyte and Ventricular Fibrosis and Ferroptosis

Transgenic expression of Cre recombinase driven by a specific promoter is normally used to conditionally knockout a gene in a tissue- or cell-type-specific manner. In αMHC-Cre transgenic mouse model, expression of Cre recombinase is controlled by the myocardial-specific α-myosin heavy chain (αMHC) p...

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Bibliographic Details
Main Authors: Zhongguang Li, Qinchun Duan, Ying Cui, Odell D. Jones, Danyang Shao, Jianfei Zhang, Yuru Gao, Xixi Cao, Shulin Wang, Jiali Li, Xinjuan Lei, Wei Zhang, Liyang Wang, Xin Zhou, Mengmeng Xu, Yingli Liu, Jianjie Ma, Xuehong Xu
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
cardiac-specific Cre
heart failure
atrial tumors
matrix metalloproteinases
calcium channel
myocardial intercalated discs
Online Access:https://www.mdpi.com/1422-0067/24/4/3094

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https://www.mdpi.com/1422-0067/24/4/3094

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