Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer
Abstract Pyroptosis, a type of inflammatory programmed cell death, is triggered by caspase cleavage of gasdermin family proteins. Based on accumulating evidence, pyroptosis is closely associated with tumour development, but the molecular mechanism underlying pyroptosis activation and the signalling...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-07-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-022-01101-6 |
| _version_ | 1818162847290490880 |
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| author | Liqing Lu Ye Zhang Xuemei Tan Yulia Merkher Sergey Leonov Li Zhu Yalan Deng Huajun zhang Dandan Zhu Yuying Tan Ying Fu Ting Liu Yongheng Chen |
| author_facet | Liqing Lu Ye Zhang Xuemei Tan Yulia Merkher Sergey Leonov Li Zhu Yalan Deng Huajun zhang Dandan Zhu Yuying Tan Ying Fu Ting Liu Yongheng Chen |
| author_sort | Liqing Lu |
| collection | DOAJ |
| description | Abstract Pyroptosis, a type of inflammatory programmed cell death, is triggered by caspase cleavage of gasdermin family proteins. Based on accumulating evidence, pyroptosis is closely associated with tumour development, but the molecular mechanism underlying pyroptosis activation and the signalling pathways regulated by pyroptosis remain unclear. In this review, we first briefly introduce the definition, morphological characteristics, and activation pathways of pyroptosis and the effect of pyroptosis on anticancer immunity. Then we review recent progress concerning the complex role of pyroptosis in various tumours. Importantly, we summarise various FDA-approved chemotherapy drugs or natural compounds that exerted antitumor properties by inducing pyroptosis of cancer cells. Moreover, we also focus on the current application of nanotechnology-induced pyroptosis in tumour therapy. In addition, some unsolved problems and potential future research directions are also raised. |
| first_indexed | 2024-12-11T16:40:10Z |
| format | Article |
| id | doaj.art-6ca0138e582e489db8e4c046710147c1 |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-12-11T16:40:10Z |
| publishDate | 2022-07-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-6ca0138e582e489db8e4c046710147c12022-12-22T00:58:20ZengNature Publishing GroupCell Death Discovery2058-77162022-07-018111310.1038/s41420-022-01101-6Emerging mechanisms of pyroptosis and its therapeutic strategy in cancerLiqing Lu0Ye Zhang1Xuemei Tan2Yulia Merkher3Sergey Leonov4Li Zhu5Yalan Deng6Huajun zhang7Dandan Zhu8Yuying Tan9Ying Fu10Ting Liu11Yongheng Chen12Department of Thoracic Surgery, Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics & State Local Joint Engineering Laboratory for Anticancer Drugs, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityDepartment of Gastroenterology, Xiangya Hospital, Central South UniversitySchool of Biological and Medical Physics, Moscow Institute of Physics and TechnologySchool of Biological and Medical Physics, Moscow Institute of Physics and TechnologyShanghai Institute of Precision Medicine, Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics & State Local Joint Engineering Laboratory for Anticancer Drugs, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics & State Local Joint Engineering Laboratory for Anticancer Drugs, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics & State Local Joint Engineering Laboratory for Anticancer Drugs, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics & State Local Joint Engineering Laboratory for Anticancer Drugs, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics & State Local Joint Engineering Laboratory for Anticancer Drugs, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityDepartment of Gastroenterology, Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics & State Local Joint Engineering Laboratory for Anticancer Drugs, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityAbstract Pyroptosis, a type of inflammatory programmed cell death, is triggered by caspase cleavage of gasdermin family proteins. Based on accumulating evidence, pyroptosis is closely associated with tumour development, but the molecular mechanism underlying pyroptosis activation and the signalling pathways regulated by pyroptosis remain unclear. In this review, we first briefly introduce the definition, morphological characteristics, and activation pathways of pyroptosis and the effect of pyroptosis on anticancer immunity. Then we review recent progress concerning the complex role of pyroptosis in various tumours. Importantly, we summarise various FDA-approved chemotherapy drugs or natural compounds that exerted antitumor properties by inducing pyroptosis of cancer cells. Moreover, we also focus on the current application of nanotechnology-induced pyroptosis in tumour therapy. In addition, some unsolved problems and potential future research directions are also raised.https://doi.org/10.1038/s41420-022-01101-6 |
| spellingShingle | Liqing Lu Ye Zhang Xuemei Tan Yulia Merkher Sergey Leonov Li Zhu Yalan Deng Huajun zhang Dandan Zhu Yuying Tan Ying Fu Ting Liu Yongheng Chen Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer Cell Death Discovery |
| title | Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer |
| title_full | Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer |
| title_fullStr | Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer |
| title_full_unstemmed | Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer |
| title_short | Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer |
| title_sort | emerging mechanisms of pyroptosis and its therapeutic strategy in cancer |
| url | https://doi.org/10.1038/s41420-022-01101-6 |
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