Gene Expression Pattern of Histone Acetylation Enzymes Changed in the Hypothalamus of Middle-Aged Female Rats: A Putative Mechanism for Female Reproductive Aging

Gene Expression Pattern of Histone Acetylation Enzymes Changed in the Hypothalamus of Middle-Aged Female Rats: A Putative Mechanism for Female Reproductive Aging

Objective: Female reproductive aging is characterized by reduced responsiveness of the hypothalamus to E2-positive feedback, which can result in alterations of gene expression and luteinizing hormone (LH) surge dysfunction. We hypothesize that age-related changes in E2-responsive gene expression are...

Full description

Bibliographic Details
Main Authors: Wen Xu, Na Zhang, Li-Sha Li, Yan Wang, Lin Wang, Mei-Rong Du, Da-Jin Li, Yan Sun
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2018-01-01
Series:Reproductive and Developmental Medicine
Subjects:
Aging; Estradiol-Positive Feedback; Estrogen Receptor-Alpha Coactivators; Histone Deacetylases; Hypothalamus
Online Access:http://www.repdevmed.org/article.asp?issn=2096-2924;year=2018;volume=2;issue=2;spage=65;epage=73;aulast=Xu

Internet

http://www.repdevmed.org/article.asp?issn=2096-2924;year=2018;volume=2;issue=2;spage=65;epage=73;aulast=Xu

Similar Items