Dexmedetomidine alleviates ferroptosis following hepatic ischemia-reperfusion injury by upregulating Nrf2/GPx4-dependent antioxidant responses

Dexmedetomidine alleviates ferroptosis following hepatic ischemia-reperfusion injury by upregulating Nrf2/GPx4-dependent antioxidant responses

Hepatic ischemia-reperfusion injury (HIRI) adversely affects liver transplant and resection outcomes. Recently, ferroptosis has been associated with HIRI. Dexmedetomidine (Dex), a potent sedative with anti-inflammatory, antioxidant, and anti-apoptotic properties, protects organs from hypoxic or isch...

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Bibliographic Details
Main Authors: Yongjun Zhang, Hua Wei, Mengmei Wang, Yang Yu, Mengyue Gu, Hui Zhong, Shuhua Dong
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Hepatic ischemia-reperfusion injury
Dexmedetomidine
Ferroptosis
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223017134

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http://www.sciencedirect.com/science/article/pii/S0753332223017134

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