IP3R-Grp75-VDAC1-MCU calcium regulation axis antagonists protect podocytes from apoptosis and decrease proteinuria in an Adriamycin nephropathy rat model

IP3R-Grp75-VDAC1-MCU calcium regulation axis antagonists protect podocytes from apoptosis and decrease proteinuria in an Adriamycin nephropathy rat model

Abstract Background The mechanism of podocyte apoptosis is not fully understood. In addition, the role of the inositol 1,4,5-triphosphate receptor (IP3R)/glucose-regulated protein 75 (Grp75)/voltage-dependent anion channel 1 (VDAC1)/mitochondrial calcium uniporter (MCU) calcium regulation axis, whic...

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Bibliographic Details
Main Authors: Han Xu, Na Guan, Ya-Li Ren, Qi-Jiao Wei, Ying-Hong Tao, Guo-Sheng Yang, Xiao-Ya Liu, Ding-Fang Bu, Ying Zhang, Sai-Nan Zhu
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Nephrology
Subjects:
Podocyte
Apoptosis
Endoplasmic reticulum mitochondria coupling
Mitochondria
Calcium
Online Access:http://link.springer.com/article/10.1186/s12882-018-0940-3

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http://link.springer.com/article/10.1186/s12882-018-0940-3

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