Patient-Derived Bone Marrow Spheroids Reveal Leukemia-Initiating Cells Supported by Mesenchymal Hypoxic Niches in Pediatric B-ALL

Patient-Derived Bone Marrow Spheroids Reveal Leukemia-Initiating Cells Supported by Mesenchymal Hypoxic Niches in Pediatric B-ALL

B-cell acute lymphoblastic leukemia (B-ALL) results from the expansion of malignant lymphoid precursors within the bone marrow (BM), where hematopoietic niches and microenvironmental signals provide leukemia-initiating cells (LICs) the conditions to survive, proliferate, initiate disease, and relaps...

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Main Authors: Juan Carlos Balandrán, José Dávila-Velderrain, Antonio Sandoval-Cabrera, Gabriela Zamora-Herrera, Vanessa Terán-Cerqueda, Lilia Adela García-Stivalet, José Alejandro Limón-Flores, Erick Armenta-Castro, Aurora Rodríguez-Martínez, Bertha Alicia Leon-Chavez, Verónica Vallejo-Ruiz, Duane C. Hassane, Sonia Mayra Pérez-Tapia, Vianney Ortiz-Navarrete, Monica L. Guzman, Rosana Pelayo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
acute lymphoblastic leukemia
leukemia-initiating cell
bone marrow niche
mesenchymal stromal cells
tumor microenvironment
B-cell development
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.746492/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.746492/full

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