TAR DNA Binding Protein-43 Loss of Function Induced by Phosphorylation at S409/410 Blocks Autophagic Flux and Participates in Secondary Brain Injury After Intracerebral Hemorrhage

TAR DNA Binding Protein-43 Loss of Function Induced by Phosphorylation at S409/410 Blocks Autophagic Flux and Participates in Secondary Brain Injury After Intracerebral Hemorrhage

This study aimed to determine the role of TAR DNA binding protein-43 (TDP-43) in intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI) and its underlying mechanisms. After ICH, expression of TDP-43 in the nucleus was significantly decreased, and its expression in the cytoplasm increase...

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Bibliographic Details
Main Authors: Liang Sun, Kai Zhang, Weiwei Zhai, Haiying Li, Haitao Shen, Zhengquan Yu, Gang Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
TDP-43
nucleus loss
mTOR
dynactin1
autophagic flux
intracerebral hemorrhage
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00079/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2018.00079/full

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