Association of fish and meat consumption with non-alcoholic fatty liver disease: Guangzhou Biobank Cohort Study
Abstract Background Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Unhealthy dietary habit is one of major risk factors of NAFLD. However, the associations between specific types of fish and meat consumption and NAFLD remain inconclusive. We explored the associat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Public Health |
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| Online Access: | https://doi.org/10.1186/s12889-023-17398-6 |
| _version_ | 1797397681338843136 |
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| author | Rui Zhen Wang Wei Sen Zhang Chao Qiang Jiang Feng Zhu Ya Li Jin Lin Xu |
| author_facet | Rui Zhen Wang Wei Sen Zhang Chao Qiang Jiang Feng Zhu Ya Li Jin Lin Xu |
| author_sort | Rui Zhen Wang |
| collection | DOAJ |
| description | Abstract Background Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Unhealthy dietary habit is one of major risk factors of NAFLD. However, the associations between specific types of fish and meat consumption and NAFLD remain inconclusive. We explored the associations of fish and meat consumption with NAFLD risk in middle-aged and older Chinese. Methods We collected information on 1,862 participants aged 50 years or older from Guangzhou Biobank Cohort Study in 2009 to 2010. Fish and meat consumption was assessed using a validated food-frequency questionnaire. NAFLD was diagnosed by ultrasound. Multivariable logistic regression was used to examine the associations of fish and meat consumption with the presence of NAFLD. Results The average age was 61.0 (standard deviation = 6.5) years for the participants, 50.2% were women, and 37.2% were diagnosed with NAFLD. After adjusting for age, sex, education, family income, occupation, smoking status, drinking status, physical activity and several metabolic traits, compared with 0 serving/week (one serving = 50 g), fatty fish consumption of ≥ 3 servings/week showed higher odds of NAFLD (odds ratio (OR) and 95% confidence interval (CI): 1.64 (1.12, 2.39)). The highest (≥ 11 servings/week of red meat and poultry; ≥ 3 servings/week of processed meat) versus the lowest (0–3 servings/week of red meat and poultry; 0 serving/week of processed meat) consumption of all other types of meats, including red meat, poultry and processed meat, showed no association with NAFLD (1.17 (0.75, 1.81), 1.02 (0.42, 2.50) and 0.85 (0.50, 1.45), respectively). Aquatic and sea food, and red meat had negative indirect effects on NAFLD via systolic blood pressure and/or high-density lipoprotein cholesterol. Processed meat had positive indirect effects on NAFLD via body mass index, waist circumference, fasting plasma glucose and triglycerides. Conclusion High consumption of fatty fish was associated with higher NAFLD risk. Our results, if causal, provide evidence that limiting consumption of fatty fish can be considered as part of NAFLD lifestyle prevention and treatment. |
| first_indexed | 2024-03-09T01:14:42Z |
| format | Article |
| id | doaj.art-6cabd24af454428c8b4fff8ef03c64bd |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-03-09T01:14:42Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-6cabd24af454428c8b4fff8ef03c64bd2023-12-10T12:34:19ZengBMCBMC Public Health1471-24582023-12-012311910.1186/s12889-023-17398-6Association of fish and meat consumption with non-alcoholic fatty liver disease: Guangzhou Biobank Cohort StudyRui Zhen Wang0Wei Sen Zhang1Chao Qiang Jiang2Feng Zhu3Ya Li Jin4Lin Xu5School of Public Health, Sun Yat-Sen UniversityGuangzhou Twelfth People’s HospitalGuangzhou Twelfth People’s HospitalGuangzhou Twelfth People’s HospitalGuangzhou Twelfth People’s HospitalSchool of Public Health, Sun Yat-Sen UniversityAbstract Background Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Unhealthy dietary habit is one of major risk factors of NAFLD. However, the associations between specific types of fish and meat consumption and NAFLD remain inconclusive. We explored the associations of fish and meat consumption with NAFLD risk in middle-aged and older Chinese. Methods We collected information on 1,862 participants aged 50 years or older from Guangzhou Biobank Cohort Study in 2009 to 2010. Fish and meat consumption was assessed using a validated food-frequency questionnaire. NAFLD was diagnosed by ultrasound. Multivariable logistic regression was used to examine the associations of fish and meat consumption with the presence of NAFLD. Results The average age was 61.0 (standard deviation = 6.5) years for the participants, 50.2% were women, and 37.2% were diagnosed with NAFLD. After adjusting for age, sex, education, family income, occupation, smoking status, drinking status, physical activity and several metabolic traits, compared with 0 serving/week (one serving = 50 g), fatty fish consumption of ≥ 3 servings/week showed higher odds of NAFLD (odds ratio (OR) and 95% confidence interval (CI): 1.64 (1.12, 2.39)). The highest (≥ 11 servings/week of red meat and poultry; ≥ 3 servings/week of processed meat) versus the lowest (0–3 servings/week of red meat and poultry; 0 serving/week of processed meat) consumption of all other types of meats, including red meat, poultry and processed meat, showed no association with NAFLD (1.17 (0.75, 1.81), 1.02 (0.42, 2.50) and 0.85 (0.50, 1.45), respectively). Aquatic and sea food, and red meat had negative indirect effects on NAFLD via systolic blood pressure and/or high-density lipoprotein cholesterol. Processed meat had positive indirect effects on NAFLD via body mass index, waist circumference, fasting plasma glucose and triglycerides. Conclusion High consumption of fatty fish was associated with higher NAFLD risk. Our results, if causal, provide evidence that limiting consumption of fatty fish can be considered as part of NAFLD lifestyle prevention and treatment.https://doi.org/10.1186/s12889-023-17398-6Non-alcoholic fatty liver diseaseFish consumptionMeat consumptionCross-sectional study |
| spellingShingle | Rui Zhen Wang Wei Sen Zhang Chao Qiang Jiang Feng Zhu Ya Li Jin Lin Xu Association of fish and meat consumption with non-alcoholic fatty liver disease: Guangzhou Biobank Cohort Study BMC Public Health Non-alcoholic fatty liver disease Fish consumption Meat consumption Cross-sectional study |
| title | Association of fish and meat consumption with non-alcoholic fatty liver disease: Guangzhou Biobank Cohort Study |
| title_full | Association of fish and meat consumption with non-alcoholic fatty liver disease: Guangzhou Biobank Cohort Study |
| title_fullStr | Association of fish and meat consumption with non-alcoholic fatty liver disease: Guangzhou Biobank Cohort Study |
| title_full_unstemmed | Association of fish and meat consumption with non-alcoholic fatty liver disease: Guangzhou Biobank Cohort Study |
| title_short | Association of fish and meat consumption with non-alcoholic fatty liver disease: Guangzhou Biobank Cohort Study |
| title_sort | association of fish and meat consumption with non alcoholic fatty liver disease guangzhou biobank cohort study |
| topic | Non-alcoholic fatty liver disease Fish consumption Meat consumption Cross-sectional study |
| url | https://doi.org/10.1186/s12889-023-17398-6 |
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