Gsmtx4 Alleviated Osteoarthritis through Piezo1/Calcineurin/NFAT1 Signaling Axis under Excessive Mechanical Strain

Gsmtx4 Alleviated Osteoarthritis through Piezo1/Calcineurin/NFAT1 Signaling Axis under Excessive Mechanical Strain

Excessive mechanical strain is the prominent risk factor for osteoarthritis (OA), causing cartilage destruction and degeneration. However, the underlying molecular mechanism contributing to mechanical signaling transduction remains unclear in OA. Piezo type mechanosensitive ion channel component 1 (...

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Bibliographic Details
Main Authors: Xunshan Ren, Huangming Zhuang, Bin Li, Fuze Jiang, Yuelong Zhang, Panghu Zhou
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
piezo1
osteoarthritis
mechanical strain
chondrocyte
Gsmtx4
Online Access:https://www.mdpi.com/1422-0067/24/4/4022

Internet

https://www.mdpi.com/1422-0067/24/4/4022

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