The molecular basis of the dichotomous functionality of MAP4K4 in proliferation and cell motility control in cancer

The molecular basis of the dichotomous functionality of MAP4K4 in proliferation and cell motility control in cancer

The finely tuned integration of intra- and extracellular cues by components of the mitogen-activated protein kinase (MAPK) signaling pathways controls the mutually exclusive phenotypic manifestations of uncontrolled growth and tumor cell dissemination. The Ser/Thr kinase MAP4K4 is an upstream integr...

Full description

Bibliographic Details
Main Authors: Dejana Jovanovic, Shen Yan, Martin Baumgartner
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Oncology
Subjects:
MAP4K4
proliferation
motility
STRIPAK complex
actin dynamics
PKC delta
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1059513/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1059513/full

Similar Items