The molecular basis of the dichotomous functionality of MAP4K4 in proliferation and cell motility control in cancer

The finely tuned integration of intra- and extracellular cues by components of the mitogen-activated protein kinase (MAPK) signaling pathways controls the mutually exclusive phenotypic manifestations of uncontrolled growth and tumor cell dissemination. The Ser/Thr kinase MAP4K4 is an upstream integr...

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Bibliographic Details
Main Authors: Dejana Jovanovic, Shen Yan, Martin Baumgartner
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1059513/full