Potential Effects of Phytoestrogen Genistein in Modulating Acute Methotrexate Chemotherapy-Induced Osteoclastogenesis and Bone Damage in Rats

Potential Effects of Phytoestrogen Genistein in Modulating Acute Methotrexate Chemotherapy-Induced Osteoclastogenesis and Bone Damage in Rats

Chemotherapy-induced bone damage is a frequent side effect which causes diminished bone mineral density and fracture in childhood cancer sufferers and survivors. The intensified use of anti-metabolite methotrexate (MTX) and other cytotoxic drugs has led to the need for a mechanistic understanding of...

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Bibliographic Details
Main Authors: Tristan J. King, Tetyana Shandala, Alice M. Lee, Bruce K. Foster, Ke-Ming Chen, Peter R. Howe, Cory J. Xian
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:International Journal of Molecular Sciences
Subjects:
methotrexate
chemotherapy
osteoporosis
genistein
Online Access:http://www.mdpi.com/1422-0067/16/8/18293

Internet

http://www.mdpi.com/1422-0067/16/8/18293

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