Multiplex CRISPR/Cas screen in regenerating haploid limbs of chimeric Axolotls

Axolotls and other salamanders can regenerate entire limbs after amputation as adults, and much recent effort has sought to identify the molecular programs controlling this process. While targeted mutagenesis approaches like CRISPR/Cas9 now permit gene-level investigation of these mechanisms, geneti...

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Bibliographic Details
Main Authors: Lucas D Sanor, Grant Parker Flowers, Craig M Crews
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/48511