Mesoporous Silica Nanoparticles Coated with Carboxymethyl Chitosan for 5-Fluorouracil Ocular Delivery: Characterization, In Vitro and In Vivo Studies

Mesoporous Silica Nanoparticles Coated with Carboxymethyl Chitosan for 5-Fluorouracil Ocular Delivery: Characterization, In Vitro and In Vivo Studies

This study investigates the development of topically applied non-invasive amino-functionalized silica nanoparticles (AMSN) and O-Carboxymethyl chitosan-coated AMSN (AMSN-CMC) for ocular delivery of 5-Fluorouracil (5-FU). Particle characterization was performed by the DLS technique (Zeta-Sizer), and...

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Bibliographic Details
Main Authors: Adel Ali Alhowyan, Mohd Abul Kalam, Muzaffar Iqbal, Mohammad Raish, Ahmed M. El-Toni, Musaed Alkholief, Aliyah A. Almomen, Aws Alshamsan
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
5-fluorouracil
mesoporous silica
nanoparticle
ocular delivery
corneal permeability study
ocular pharmacokinetic
Online Access:https://www.mdpi.com/1420-3049/28/3/1260

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https://www.mdpi.com/1420-3049/28/3/1260

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