The Mechanism of Chromatin Remodeler SMARCAD1/Fun30 in Response to DNA Damage
DNA packs into highly condensed chromatin to organize the genome in eukaryotes but occludes many regulatory DNA elements. Access to DNA within nucleosomes is therefore required for a variety of biological processes in cells including transcription, replication, and DNA repair. To cope with this prob...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2020.560098/full |
| _version_ | 1818244596326465536 |
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| author | Ze-Bin Tong Ze-Bin Tong Hua-Song Ai Jia-Bin Li |
| author_facet | Ze-Bin Tong Ze-Bin Tong Hua-Song Ai Jia-Bin Li |
| author_sort | Ze-Bin Tong |
| collection | DOAJ |
| description | DNA packs into highly condensed chromatin to organize the genome in eukaryotes but occludes many regulatory DNA elements. Access to DNA within nucleosomes is therefore required for a variety of biological processes in cells including transcription, replication, and DNA repair. To cope with this problem, cells employ a set of specialized ATP-dependent chromatin-remodeling protein complexes to enable dynamic access to packaged DNA. In the present review, we summarize the recent advances in the functional and mechanistic studies on a particular chromatin remodeler SMARCAD1Fun30 which has been demonstrated to play a key role in distinct cellular processes and gained much attention in recent years. Focus is given to how SMARCAD1Fun30 regulates various cellular processes through its chromatin remodeling activity, and especially the regulatory role of SMARCAD1Fun30 in gene expression control, maintenance and establishment of heterochromatin, and DNA damage repair. Moreover, we review the studies on the molecular mechanism of SMARCAD1Fun30 that promotes the DNA end-resection on double-strand break ends, including the mechanisms of recruitment, activity regulation and chromatin remodeling. |
| first_indexed | 2024-12-12T14:19:32Z |
| format | Article |
| id | doaj.art-6cbbf338a1194061930438b735770d64 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T14:19:32Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-6cbbf338a1194061930438b735770d642022-12-22T00:21:49ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-09-01810.3389/fcell.2020.560098560098The Mechanism of Chromatin Remodeler SMARCAD1/Fun30 in Response to DNA DamageZe-Bin Tong0Ze-Bin Tong1Hua-Song Ai2Jia-Bin Li3College of Pharmaceutical Sciences, Soochow University, Suzhou, ChinaMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, ChinaMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, ChinaCollege of Pharmaceutical Sciences, Soochow University, Suzhou, ChinaDNA packs into highly condensed chromatin to organize the genome in eukaryotes but occludes many regulatory DNA elements. Access to DNA within nucleosomes is therefore required for a variety of biological processes in cells including transcription, replication, and DNA repair. To cope with this problem, cells employ a set of specialized ATP-dependent chromatin-remodeling protein complexes to enable dynamic access to packaged DNA. In the present review, we summarize the recent advances in the functional and mechanistic studies on a particular chromatin remodeler SMARCAD1Fun30 which has been demonstrated to play a key role in distinct cellular processes and gained much attention in recent years. Focus is given to how SMARCAD1Fun30 regulates various cellular processes through its chromatin remodeling activity, and especially the regulatory role of SMARCAD1Fun30 in gene expression control, maintenance and establishment of heterochromatin, and DNA damage repair. Moreover, we review the studies on the molecular mechanism of SMARCAD1Fun30 that promotes the DNA end-resection on double-strand break ends, including the mechanisms of recruitment, activity regulation and chromatin remodeling.https://www.frontiersin.org/article/10.3389/fcell.2020.560098/fullSMARCAD1/Fun30chromatin remodelerDNA damageDNA end-resectionsingle-stranded DNApost-translational modification |
| spellingShingle | Ze-Bin Tong Ze-Bin Tong Hua-Song Ai Jia-Bin Li The Mechanism of Chromatin Remodeler SMARCAD1/Fun30 in Response to DNA Damage Frontiers in Cell and Developmental Biology SMARCAD1/Fun30 chromatin remodeler DNA damage DNA end-resection single-stranded DNA post-translational modification |
| title | The Mechanism of Chromatin Remodeler SMARCAD1/Fun30 in Response to DNA Damage |
| title_full | The Mechanism of Chromatin Remodeler SMARCAD1/Fun30 in Response to DNA Damage |
| title_fullStr | The Mechanism of Chromatin Remodeler SMARCAD1/Fun30 in Response to DNA Damage |
| title_full_unstemmed | The Mechanism of Chromatin Remodeler SMARCAD1/Fun30 in Response to DNA Damage |
| title_short | The Mechanism of Chromatin Remodeler SMARCAD1/Fun30 in Response to DNA Damage |
| title_sort | mechanism of chromatin remodeler smarcad1 fun30 in response to dna damage |
| topic | SMARCAD1/Fun30 chromatin remodeler DNA damage DNA end-resection single-stranded DNA post-translational modification |
| url | https://www.frontiersin.org/article/10.3389/fcell.2020.560098/full |
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