LRP1 is a neuronal receptor for α-synuclein uptake and spread

LRP1 is a neuronal receptor for α-synuclein uptake and spread

Abstract Background The aggregation and spread of α-synuclein (α-Syn) protein and related neuronal toxicity are the key pathological features of Parkinson’s disease (PD) and Lewy body dementia (LBD). Studies have shown that pathological species of α-Syn and tau can spread in a prion-like manner betw...

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Bibliographic Details
Main Authors: Kai Chen, Yuka A. Martens, Axel Meneses, Daniel H. Ryu, Wenyan Lu, Ana Caroline Raulin, Fuyao Li, Jing Zhao, Yixing Chen, Yunjung Jin, Cynthia Linares, Marshall Goodwin, Yonghe Li, Chia-Chen Liu, Takahisa Kanekiyo, David M. Holtzman, Todd E. Golde, Guojun Bu, Na Zhao
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Molecular Neurodegeneration
Subjects:
Low-density lipoprotein receptor-related protein 1
α-Synuclein
Human induced pluripotent stem cells
Parkinson’s disease
Lewy body dementia
Online Access:https://doi.org/10.1186/s13024-022-00560-w

Internet

https://doi.org/10.1186/s13024-022-00560-w

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